Why Your Antidepressants Seem to Stop Working – And What To Do

You’ve been on the same antidepressant for years. Then suddenly, the medication seems to stop working.

The problem can hit people even when a drug has worked well for a decade or more. Symptoms such as persistent sadness and a loss of interest in favorite activities resurge. Identifying the right solution can be difficult and largely trial-and-error: Some patients may need a higher dose of the same medication, while others may need to try a new drug or a new combination of drugs, doctors say.

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